1. Nilsson, J, Ashton, NJ, Benedet, AL, Montoliu-Gaya, L, Gobom, J, Pascoal, TA et al.. Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer’s disease. Alzheimers Res Ther. 2022;14 (1):78. doi: 10.1186/s13195-022-01021-8. PubMed PMID:35659284 .
  2. Karikari, TK, Ashton, NJ, Brinkmalm, G, Brum, WS, Benedet, AL, Montoliu-Gaya, L et al.. Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility. Nat Rev Neurol. 2022; :. doi: 10.1038/s41582-022-00665-2. PubMed PMID:35585226 .
  3. Xie, K, Chen, Y, Chu, M, Cui, Y, Chen, Z, Zhang, J et al.. Specific structuro-metabolic pattern of thalamic subnuclei in fatal familial insomnia: A PET/MRI imaging study. Neuroimage Clin. 2022;34 :103026. doi: 10.1016/j.nicl.2022.103026. PubMed PMID:35504222 PubMed Central PMC9065920.
  4. Chu, M, Xie, K, Zhang, J, Chen, Z, Ghorayeb, I, Rupprecht, S et al.. Proposal of new diagnostic criteria for fatal familial insomnia. J Neurol. 2022; :. doi: 10.1007/s00415-022-11135-6. PubMed PMID:35501502 .
  5. Bdair, H, Singleton, TA, Ross, K, Jolly, D, Kang, MS, Aliaga, A et al.. Radiosynthesis and In Vivo Evaluation of Four Positron Emission Tomography Tracer Candidates for Imaging of Melatonin Receptors. ACS Chem Neurosci. 2022;13 (9):1382-1394. doi: 10.1021/acschemneuro.1c00678. PubMed PMID:35420022 .
  6. Liu, L, Chu, M, Nie, B, Liu, L, Xie, K, Cui, Y et al.. Reconfigured metabolism brain network in asymptomatic microtubule-associated protein tau mutation carriers: a graph theoretical analysis. Alzheimers Res Ther. 2022;14 (1):52. doi: 10.1186/s13195-022-01000-z. PubMed PMID:35410286 PubMed Central PMC8996677.
  7. Brum, WS, de Bastiani, MA, Bieger, A, Therriault, J, Ferrari-Souza, JP, Benedet, AL et al.. A three-range approach enhances the prognostic utility of CSF biomarkers in Alzheimer’s disease. Alzheimers Dement (N Y). 2022;8 (1):e12270. doi: 10.1002/trc2.12270. PubMed PMID:35310530 PubMed Central PMC8918110.
  8. Hopewell, R, Jolly, D, Li, QY, Ross, K, Tsai, IH, Lacatus-Samoila, M et al.. High-yielding, automated radiosynthesis of [11 C]martinostat using [11 C]methyl triflate. J Labelled Comp Radiopharm. 2022;65 (6):167-173. doi: 10.1002/jlcr.3968. PubMed PMID:35218059 .
  9. Cassidy, CM, Therriault, J, Pascoal, TA, Cheung, V, Savard, M, Tuominen, L et al.. Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer’s disease. Neuropsychopharmacology. 2022;47 (5):1128-1136. doi: 10.1038/s41386-022-01293-6. PubMed PMID:35177805 PubMed Central PMC8938499.
  10. Ashton, NJ, Benedet, AL, Pascoal, TA, Karikari, TK, Lantero-Rodriguez, J, Brum, WS et al.. Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer’s disease. EBioMedicine. 2022;76 :103836. doi: 10.1016/j.ebiom.2022.103836. PubMed PMID:35158308 PubMed Central PMC8850760.
  11. Ziff, OJ, Ashton, NJ, Mehta, PR, Brown, R, Athauda, D, Heaney, J et al.. Amyloid processing in COVID-19-associated neurological syndromes. J Neurochem. 2022;161 (2):146-157. doi: 10.1111/jnc.15585. PubMed PMID:35137414 PubMed Central PMC9115071.
  12. Tissot, C, Therriault, J, Kunach, P, L Benedet, A, Pascoal, TA, Ashton, NJ et al.. Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET. EBioMedicine. 2022;76 :103837. doi: 10.1016/j.ebiom.2022.103837. PubMed PMID:35134647 PubMed Central PMC8844756.
  13. Rocha, A, Bellaver, B, Souza, DG, Schu, G, Fontana, IC, Venturin, GT et al.. Clozapine induces astrocyte-dependent FDG-PET hypometabolism. Eur J Nucl Med Mol Imaging. 2022;49 (7):2251-2264. doi: 10.1007/s00259-022-05682-3. PubMed PMID:35122511 .
  14. Jansen, WJ, Janssen, O, Tijms, BM, Vos, SJB, Ossenkoppele, R, Visser, PJ et al.. Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum. JAMA Neurol. 2022;79 (3):228-243. doi: 10.1001/jamaneurol.2021.5216. PubMed PMID:35099509 .
  15. Savard, M, Pascoal, TA, Servaes, S, Dhollander, T, Iturria-Medina, Y, Kang, MS et al.. Impact of long- and short-range fibre depletion on the cognitive deficits of fronto-temporal dementia. Elife. 2022;11 :. doi: 10.7554/eLife.73510. PubMed PMID:35073256 PubMed Central PMC8824472.
  16. Terada, T, Therriault, J, Kang, MS, Savard, M, Pascoal, TA, Lussier, F et al.. Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer’s disease. Eur J Neurol. 2022;29 (5):1324-1334. doi: 10.1111/ene.15246. PubMed PMID:35007366 .
  17. Kwan, C, Kang, MS, Nuara, SG, Gourdon, JC, Bédard, D, Tardif, CL et al.. Co-registration of Imaging Modalities (MRI, CT and PET) to Perform Frameless Stereotaxic Robotic Injections in the Common Marmoset. Neuroscience. 2022;480 :143-154. doi: 10.1016/j.neuroscience.2021.11.009. PubMed PMID:34774970 .
  18. Gobom, J, Parnetti, L, Rosa-Neto, P, Vyhnalek, M, Gauthier, S, Cataldi, S et al.. Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal fluid. Clin Chem Lab Med. 2022;60 (2):207-219. doi: 10.1515/cclm-2021-0651. PubMed PMID:34773730 .
  19. Levy, JP, Bezgin, G, Savard, M, Pascoal, TA, Finger, E, Laforce, R et al.. 18F-MK-6240 tau-PET in genetic frontotemporal dementia. Brain. 2022;145 (5):1763-1772. doi: 10.1093/brain/awab392. PubMed PMID:34664612 .
  20. Picard, C, Nilsson, N, Labonté, A, Auld, D, Rosa-Neto, P, Alzheimer’s Disease Neuroimaging Initiative et al.. Apolipoprotein B is a novel marker for early tau pathology in Alzheimer’s disease. Alzheimers Dement. 2022;18 (5):875-887. doi: 10.1002/alz.12442. PubMed PMID:34590423 .
  21. Kang, MS, Shin, M, Ottoy, J, Aliaga, AA, Mathotaarachchi, S, Quispialaya, K et al.. Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer’s disease therapeutic. J Cereb Blood Flow Metab. 2022;42 (5):788-801. doi: 10.1177/0271678X211035625. PubMed PMID:34378436 PubMed Central PMC9014686.


  1. Therriault, J, Pascoal, T, Gauthier, S, Rosa-Neto, P. Author Response: Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE ε4, and Cognitive Impairment. Neurology. 2021;97 (12):609. doi: 10.1212/WNL.0000000000012586. PubMed PMID:35100130 .
  2. Povala, G, Bellaver, B, De Bastiani, MA, Brum, WS, Ferreira, PCL, Bieger, A et al.. Soluble amyloid-beta isoforms predict downstream Alzheimer’s disease pathology. Cell Biosci. 2021;11 (1):204. doi: 10.1186/s13578-021-00712-3. PubMed PMID:34895338 PubMed Central PMC8665586.
  3. Janssen, O, Jansen, WJ, Vos, SJB, Boada, M, Parnetti, L, Gabryelewicz, T et al.. Characteristics of subjective cognitive decline associated with amyloid positivity. Alzheimers Dement. 2021; :. doi: 10.1002/alz.12512. PubMed PMID:34877782 .
  4. Lantero-Rodriguez, J, Snellman, A, Benedet, AL, Milà-Alomà, M, Camporesi, E, Montoliu-Gaya, L et al.. P-tau235: a novel biomarker for staging preclinical Alzheimer’s disease. EMBO Mol Med. 2021;13 (12):e15098. doi: 10.15252/emmm.202115098. PubMed PMID:34725927 PubMed Central PMC8649868.
  5. Chu, M, Liu, L, Wang, J, Liu, L, Kong, Y, Jing, D et al.. Investigating the Roles of Anterior Cingulate in Behavioral Variant Frontotemporal Dementia: A PET/MRI Study. J Alzheimers Dis. 2021;84 (4):1771-1779. doi: 10.3233/JAD-215127. PubMed PMID:34719498 PubMed Central PMC8764589.
  6. Benedet, AL, Milà-Alomà, M, Vrillon, A, Ashton, NJ, Pascoal, TA, Lussier, F et al.. Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum. JAMA Neurol. 2021;78 (12):1471-1483. doi: 10.1001/jamaneurol.2021.3671. PubMed PMID:34661615 PubMed Central PMC8524356.
  7. Pascoal, TA, Benedet, AL, Ashton, NJ, Kang, MS, Therriault, J, Chamoun, M et al.. Publisher Correction: Microglial activation and tau propagate jointly across Braak stages. Nat Med. 2021;27 (11):2048-2049. doi: 10.1038/s41591-021-01568-3. PubMed PMID:34654920 .
  8. Legault-Denis, C, Aghourian, M, Soucy, JP, Rosa-Neto, P, Dagher, A, Aumont, E et al.. Normal cognition in Parkinson’s disease may involve hippocampal cholinergic compensation: An exploratory PET imaging study with [18F]-FEOBV. Parkinsonism Relat Disord. 2021;91 :162-166. doi: 10.1016/j.parkreldis.2021.09.018. PubMed PMID:34628195 .
  9. Therriault, J, Pascoal, TA, Sefranek, M, Mathotaarachchi, S, Benedet, AL, Chamoun, M et al.. Amyloid-dependent and amyloid-independent effects of Tau in individuals without dementia. Ann Clin Transl Neurol. 2021;8 (10):2083-2092. doi: 10.1002/acn3.51457. PubMed PMID:34617688 PubMed Central PMC8528464.
  10. Gauthier, S, Rosa-Neto, P. Commentary: The US Expert Panel on the Appropriate Use Recommendations of Aducanumab in Clinical Practice. J Prev Alzheimers Dis. 2021;8 (4):411. doi: 10.14283/jpad.2021.44. PubMed PMID:34585213 .
  11. Lindberg, A, Mossine, AV, Aliaga, A, Hopewell, R, Massarweh, G, Rosa-Neto, P et al.. Preliminary Evaluations of [11C]Verubulin: Implications for Microtubule Imaging With PET. Front Neurosci. 2021;15 :725873. doi: 10.3389/fnins.2021.725873. PubMed PMID:34566568 PubMed Central PMC8456034.
  12. Kanel, P, Bedard, MA, Aghourian, M, Rosa-Neto, P, Soucy, JP, Albin, RL et al.. Molecular Imaging of the Cholinergic System in Alzheimer and Lewy Body Dementias: Expanding Views. Curr Neurol Neurosci Rep. 2021;21 (10):52. doi: 10.1007/s11910-021-01140-z. PubMed PMID:34545424 PubMed Central PMC9020458.
  13. Pascoal, TA, Benedet, AL, Tudorascu, DL, Therriault, J, Mathotaarachchi, S, Savard, M et al.. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain. 2021;144 (11):3517-3528. doi: 10.1093/brain/awab248. PubMed PMID:34515754 PubMed Central PMC8677534.
  14. Aghourian, M, Aumont, É, Grothe, MJ, Soucy, JP, Rosa-Neto, P, Bedard, MA et al.. FEOBV-PET to quantify cortical cholinergic denervation in AD: Relationship to basal forebrain volumetry. J Neuroimaging. 2021;31 (6):1077-1081. doi: 10.1111/jon.12921. PubMed PMID:34462992 .
  15. Pascoal, TA, Benedet, AL, Ashton, NJ, Kang, MS, Therriault, J, Chamoun, M et al.. Microglial activation and tau propagate jointly across Braak stages. Nat Med. 2021;27 (9):1592-1599. doi: 10.1038/s41591-021-01456-w. PubMed PMID:34446931 .
  16. Paterson, RW, Benjamin, LA, Mehta, PR, Brown, RL, Athauda, D, Ashton, NJ et al.. Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological syndromes. Brain Commun. 2021;3 (3):fcab099. doi: 10.1093/braincomms/fcab099. PubMed PMID:34396099 PubMed Central PMC8194666.
  17. Boyle, AJ, Gaudet, VC, Black, SE, Vasdev, N, Rosa-Neto, P, Zukotynski, KA et al.. Artificial intelligence for molecular neuroimaging. Ann Transl Med. 2021;9 (9):822. doi: 10.21037/atm-20-6220. PubMed PMID:34268435 PubMed Central PMC8246223.
  18. Therriault, J, Benedet, AL, Pascoal, TA, Lussier, FZ, Tissot, C, Karikari, TK et al.. Association of plasma P-tau181 with memory decline in non-demented adults. Brain Commun. 2021;3 (3):fcab136. doi: 10.1093/braincomms/fcab136. PubMed PMID:34222875 PubMed Central PMC8249102.
  19. Tremblay-Mercier, J, Madjar, C, Das, S, Pichet Binette, A, Dyke, SOM, Étienne, P et al.. Open science datasets from PREVENT-AD, a longitudinal cohort of pre-symptomatic Alzheimer’s disease. Neuroimage Clin. 2021;31 :102733. doi: 10.1016/j.nicl.2021.102733. PubMed PMID:34192666 PubMed Central PMC8254111.
  20. Wang, YT, Pascoal, TA, Therriault, J, Kang, MS, Benedet, AL, Savard, M et al.. Interactive rather than independent effect of APOE and sex potentiates tau deposition in women. Brain Commun. 2021;3 (2):fcab126. doi: 10.1093/braincomms/fcab126. PubMed PMID:34189460 PubMed Central PMC8226193.
  21. Ashton, NJ, Janelidze, S, Al Khleifat, A, Leuzy, A, van der Ende, EL, Karikari, TK et al.. A multicentre validation study of the diagnostic value of plasma neurofilament light. Nat Commun. 2021;12 (1):3400. doi: 10.1038/s41467-021-23620-z. PubMed PMID:34099648 PubMed Central PMC8185001.
  22. Lam, J, DuBois, JM, Rowley, J, Rousset, OG, González-Otárula, KA, Soucy, JP et al.. In vivo hippocampal cornu ammonis 1-3 glutamatergic abnormalities are associated with temporal lobe epilepsy surgery outcomes. Epilepsia. 2021;62 (7):1559-1568. doi: 10.1111/epi.16952. PubMed PMID:34060082 .
  23. Leuzy, A, Pascoal, TA, Strandberg, O, Insel, P, Smith, R, Mattsson-Carlgren, N et al.. A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis. Eur J Nucl Med Mol Imaging. 2021;48 (7):2295-2305. doi: 10.1007/s00259-021-05401-4. PubMed PMID:34041562 PubMed Central PMC8175317.
  24. Ng, KP, Cheng, GH, Yatawara, C, Rosa-Neto, P, Gauthier, S, Kandiah, N et al.. Baseline Neurodegeneration Influences the Longitudinal Effects of Tau on Cognition. J Alzheimers Dis. 2021;82 (1):159-167. doi: 10.3233/JAD-201425. PubMed PMID:33998536 .
  25. Lussier, FZ, Benedet, AL, Therriault, J, Pascoal, TA, Tissot, C, Chamoun, M et al.. Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive individuals. Brain Commun. 2021;3 (2):fcab073. doi: 10.1093/braincomms/fcab073. PubMed PMID:33959711 PubMed Central PMC8088291.
  26. Bellaver, B, Ferrari-Souza, JP, Uglione da Ros, L, Carter, SF, Rodriguez-Vieitez, E, Nordberg, A et al.. Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-analysis. Neurology. 2021; :. doi: 10.1212/WNL.0000000000012109. PubMed PMID:33952650 .
  27. Lyra E Silva, NM, Gonçalves, RA, Pascoal, TA, Lima-Filho, RAS, Resende, EPF, Vieira, ELM et al.. Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease. Transl Psychiatry. 2021;11 (1):251. doi: 10.1038/s41398-021-01349-z. PubMed PMID:33911072 PubMed Central PMC8080782.
  28. Terada, T, Therriault, J, Kang, MSP, Savard, M, Pascoal, TA, Lussier, F et al.. Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer’s disease. Mol Neurodegener. 2021;16 (1):28. doi: 10.1186/s13024-021-00448-1. PubMed PMID:33902654 PubMed Central PMC8074456.
  29. Tissot, C, Therriault, J, Pascoal, TA, Chamoun, M, Lussier, FZ, Savard, M et al.. Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer’s disease. Alzheimers Dement (N Y). 2021;7 (1):e12154. doi: 10.1002/trc2.12154. PubMed PMID:33816761 PubMed Central PMC8012244.
  30. Ng, KP, Chiew, H, Rosa-Neto, P, Kandiah, N, Ismail, Z, Gauthier, S et al.. Associations of AT(N) biomarkers with neuropsychiatric symptoms in preclinical Alzheimer’s disease and cognitively unimpaired individuals. Transl Neurodegener. 2021;10 (1):11. doi: 10.1186/s40035-021-00236-3. PubMed PMID:33789730 PubMed Central PMC8011383.
  31. Tissot, C, L Benedet, A, Therriault, J, Pascoal, TA, Lussier, FZ, Saha-Chaudhuri, P et al.. Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer’s disease. Alzheimers Res Ther. 2021;13 (1):69. doi: 10.1186/s13195-021-00802-x. PubMed PMID:33781319 PubMed Central PMC8008680.
  32. Ashton, NJ, Pascoal, TA, Karikari, TK, Benedet, AL, Lantero-Rodriguez, J, Brinkmalm, G et al.. Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology. Acta Neuropathol. 2021;141 (5):709-724. doi: 10.1007/s00401-021-02275-6. PubMed PMID:33585983 PubMed Central PMC8043944.
  33. Simrén, J, Leuzy, A, Karikari, TK, Hye, A, Benedet, AL, Lantero-Rodriguez, J et al.. The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer’s disease. Alzheimers Dement. 2021;17 (7):1145-1156. doi: 10.1002/alz.12283. PubMed PMID:33491853 PubMed Central PMC8359457.
  34. Therriault, J, Pascoal, TA, Benedet, AL, Tissot, C, Savard, M, Chamoun, M et al.. Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE ε4, and Cognitive Impairment. Neurology. 2021;96 (7):e975-e985. doi: 10.1212/WNL.0000000000011416. PubMed PMID:33443136 PubMed Central PMC8055338.
  35. DuBois, JM, Mathotaarachchi, S, Rousset, OG, Sziklas, V, Sepulcre, J, Guiot, MC et al.. Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia. Neuroimage Clin. 2021;29 :102552. doi: 10.1016/j.nicl.2020.102552. PubMed PMID:33401137 PubMed Central PMC7787952.
  36. Ng, KP, Pascoal, TA, Mathotaarachchi, S, Chan, YH, Jiang, L, Therriault, J et al.. Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer’s disease. Transl Neurodegener. 2021;10 (1):1. doi: 10.1186/s40035-020-00225-y. PubMed PMID:33390174 PubMed Central PMC7780680.
  37. Karikari, TK, Benedet, AL, Ashton, NJ, Lantero Rodriguez, J, Snellman, A, Suárez-Calvet, M et al.. Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative. Mol Psychiatry. 2021;26 (2):429-442. doi: 10.1038/s41380-020-00923-z. PubMed PMID:33106600 .
  38. Therriault, J, Pascoal, TA, Savard, M, Benedet, AL, Chamoun, M, Tissot, C et al.. Topographic Distribution of Amyloid-β, Tau, and Atrophy in Patients With Behavioral/Dysexecutive Alzheimer Disease. Neurology. 2021;96 (1):e81-e92. doi: 10.1212/WNL.0000000000011081. PubMed PMID:33093220 PubMed Central PMC7884976.
  39. Cristini, J, Weiss, M, De Las Heras, B, Medina-Rincón, A, Dagher, A, Postuma, RB et al.. The effects of exercise on sleep quality in persons with Parkinson’s disease: A systematic review with meta-analysis. Sleep Med Rev. 2021;55 :101384. doi: 10.1016/j.smrv.2020.101384. PubMed PMID:32987321 .
  40. Zukotynski, K, Gaudet, V, Uribe, CF, Mathotaarachchi, S, Smith, KC, Rosa-Neto, P et al.. Machine Learning in Nuclear Medicine: Part 2-Neural Networks and Clinical Aspects. J Nucl Med. 2021;62 (1):22-29. doi: 10.2967/jnumed.119.231837. PubMed PMID:32978286 .
  41. van den Brink, SEM, El Amrani, L, Therriault, J, Gauthier, S, Rosa-Neto, P, Vitali, P et al.. Diagnostic Impact of Cerebrospinal Fluid Biomarkers in Atypical Dementias in Canada. Can J Neurol Sci. 2021;48 (3):312-320. doi: 10.1017/cjn.2020.196. PubMed PMID:32892784 .
  42. Therriault, J, Benedet, AL, Pascoal, TA, Savard, M, Ashton, NJ, Chamoun, M et al.. Determining Amyloid-β Positivity Using 18F-AZD4694 PET Imaging. J Nucl Med. 2021;62 (2):247-252. doi: 10.2967/jnumed.120.245209. PubMed PMID:32737243 .
  43. Kang, MS, Aliaga, AA, Shin, M, Mathotaarachchi, S, Benedet, AL, Pascoal, TA et al.. Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease. Mol Psychiatry. 2021;26 (10):5989-6001. doi: 10.1038/s41380-020-0818-1. PubMed PMID:32591633 PubMed Central PMC8758474.
  44. Smart, K, Nagano-Saito, A, Milella, MS, Sakae, DY, Favier, M, Vigneault, E et al.. Metabotropic glutamate type 5 receptor binding availability during dextroamphetamine sensitization in mice and humans. J Psychiatry Neurosci. 2021;46 (1):E1-E13. doi: 10.1503/jpn.190162. PubMed PMID:32559027 PubMed Central PMC7955855.
  45. Therriault, J, Benedet, AL, Pascoal, TA, Mathotaarachchi, S, Savard, M, Chamoun, M et al.. APOEε4 potentiates the relationship between amyloid-β and tau pathologies. Mol Psychiatry. 2021;26 (10):5977-5988. doi: 10.1038/s41380-020-0688-6. PubMed PMID:32161362 PubMed Central PMC8758492.


  1. Brisson, M, Brodeur, C, Létourneau-Guillon, L, Masellis, M, Stoessl, J, Tamm, A et al.. CCCDTD5: Clinical role of neuroimaging and liquid biomarkers in patients with cognitive impairment. Alzheimers Dement (N Y). 2020;6 (1):e12098. doi: 10.1002/trc2.12098. PubMed PMID:33532543 PubMed Central PMC7821956.
  2. Ng, KP, Chiew, HJ, Hameed, S, Ting, SKS, Ng, A, Soo, SA et al.. Frontotemporal dementia and COVID-19: Hypothesis generation and roadmap for future research. Alzheimers Dement (N Y). 2020;6 (1):e12085. doi: 10.1002/trc2.12085. PubMed PMID:33490361 PubMed Central PMC7810128.
  3. Tian Hui Kwan, A, Arfaie, S, Therriault, J, Rosa-Neto, P, Gauthier, S. Lessons Learnt from the Second Generation of Anti-Amyloid Monoclonal Antibodies Clinical Trials. Dement Geriatr Cogn Disord. 2020;49 (4):334-348. doi: 10.1159/000511506. PubMed PMID:33321511 .
  4. Paquin, V, Therriault, J, Pascoal, TA, Rosa-Neto, P, Gauthier, S. Frontal Variant of Alzheimer Disease Differentiated From Frontotemporal Dementia Using in Vivo Amyloid and Tau Imaging. Cogn Behav Neurol. 2020;33 (4):288-293. doi: 10.1097/WNN.0000000000000251. PubMed PMID:33264158 .
  5. Benedet, AL, Leuzy, A, Pascoal, TA, Ashton, NJ, Mathotaarachchi, S, Savard, M et al.. Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer’s disease. Brain. 2020;143 (12):3793-3804. doi: 10.1093/brain/awaa342. PubMed PMID:33210117 PubMed Central PMC7805809.
  6. Gauthier, S, Therriault, J, Pascoal, T, Rosa-Neto, P. Impact of p-tau181 and p-tau217 levels on enrollment for randomized clinical trials and future use of anti-amyloid and anti-tau drugs. Expert Rev Neurother. 2020;20 (12):1211-1213. doi: 10.1080/14737175.2020.1841637. PubMed PMID:33094676 .
  7. Gauthier, S, Chertkow, H, Theriault, J, Chayer, C, Ménard, MC, Lacombe, G et al.. CCCDTD5: research diagnostic criteria for Alzheimer’s Disease. Alzheimers Dement (N Y). 2020;6 (1):e12036. doi: 10.1002/trc2.12036. PubMed PMID:32864413 PubMed Central PMC7446944.
  8. Ismail, Z, Black, SE, Camicioli, R, Chertkow, H, Herrmann, N, Laforce, R Jr et al.. Recommendations of the 5th Canadian Consensus Conference on the diagnosis and treatment of dementia. Alzheimers Dement. 2020;16 (8):1182-1195. doi: 10.1002/alz.12105. PubMed PMID:32725777 PubMed Central PMC7984031.
  9. Pascoal, TA, Therriault, J, Benedet, AL, Savard, M, Lussier, FZ, Chamoun, M et al.. 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain. 2020;143 (9):2818-2830. doi: 10.1093/brain/awaa180. PubMed PMID:32671408 .
  10. Pascoal, TA, Therriault, J, Mathotaarachchi, S, Kang, MS, Shin, M, Benedet, AL et al.. Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment. Alzheimers Dement (Amst). 2020;12 (1):e12037. doi: 10.1002/dad2.12037. PubMed PMID:32582834 PubMed Central PMC7306519.
  11. Sheynin, Y, Rosa-Neto, P, Hess, RF, Vaucher, E. Cholinergic Modulation of Binocular Vision. J Neurosci. 2020;40 (27):5208-5213. doi: 10.1523/JNEUROSCI.2484-19.2020. PubMed PMID:32457075 PubMed Central PMC7329301.
  12. Karikari, TK, Pascoal, TA, Ashton, NJ, Janelidze, S, Benedet, AL, Rodriguez, JL et al.. Blood phosphorylated tau 181 as a biomarker for Alzheimer’s disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. Lancet Neurol. 2020;19 (5):422-433. doi: 10.1016/S1474-4422(20)30071-5. PubMed PMID:32333900 .
  13. Knudsen, GM, Ganz, M, Appelhoff, S, Boellaard, R, Bormans, G, Carson, RE et al.. Guidelines for the content and format of PET brain data in publications and archives: A consensus paper. J Cereb Blood Flow Metab. 2020;40 (8):1576-1585. doi: 10.1177/0271678X20905433. PubMed PMID:32065076 PubMed Central PMC7370374.
  14. Pichet Binette, A, Gonneaud, J, Vogel, JW, La Joie, R, Rosa-Neto, P, Collins, DL et al.. Morphometric network differences in ageing versus Alzheimer’s disease dementia. Brain. 2020;143 (2):635-649. doi: 10.1093/brain/awz414. PubMed PMID:32040564 PubMed Central PMC7009528.
  15. Köbe, T, Gonneaud, J, Pichet Binette, A, Meyer, PF, McSweeney, M, Rosa-Neto, P et al.. Association of Vascular Risk Factors With β-Amyloid Peptide and Tau Burdens in Cognitively Unimpaired Individuals and Its Interaction With Vascular Medication Use. JAMA Netw Open. 2020;3 (2):e1920780. doi: 10.1001/jamanetworkopen.2019.20780. PubMed PMID:32031648 .
  16. McSweeney, M, Pichet Binette, A, Meyer, PF, Gonneaud, J, Bedetti, C, Ozlen, H et al.. Intermediate flortaucipir uptake is associated with Aβ-PET and CSF tau in asymptomatic adults. Neurology. 2020;94 (11):e1190-e1200. doi: 10.1212/WNL.0000000000008905. PubMed PMID:32015176 .
  17. Dehghani, M, Zhang, S, Kumaragamage, C, Rosa-Neto, P, Near, J. Dynamic 1 H-MRS for detection of 13 C-labeled glucose metabolism in the human brain at 3T. Magn Reson Med. 2020;84 (3):1140-1151. doi: 10.1002/mrm.28188. PubMed PMID:32003052 .
  18. Singleton, TA, Bdair, H, Bailey, JJ, Choi, S, Aliaga, A, Rosa-Neto, P et al.. Efficient radiosynthesis and preclinical evaluation of [18 F]FOMPyD as a positron emission tomography tracer candidate for TrkB/C receptor imaging. J Labelled Comp Radiopharm. 2020;63 (3):144-150. doi: 10.1002/jlcr.3827. PubMed PMID:31919878 .
  19. Lussier, FZ, Pascoal, TA, Chamoun, M, Therriault, J, Tissot, C, Savard, M et al.. Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals. Alzheimers Dement. 2020;16 (1):192-199. doi: 10.1002/alz.12007. PubMed PMID:31914223 PubMed Central PMC7041633.
  20. Therriault, J, Benedet, AL, Pascoal, TA, Mathotaarachchi, S, Chamoun, M, Savard, M et al.. Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β. JAMA Neurol. 2020;77 (4):470-479. doi: 10.1001/jamaneurol.2019.4421. PubMed PMID:31860000 PubMed Central PMC6990684.
  21. Ng, KP, Richard-Devantoy, S, Bertrand, JA, Jiang, L, Pascoal, TA, Mathotaarachchi, S et al.. Suicidal ideation is common in autosomal dominant Alzheimer’s disease at-risk persons. Int J Geriatr Psychiatry. 2020;35 (1):60-68. doi: 10.1002/gps.5215. PubMed PMID:31642105 PubMed Central PMC7232741.


  1. Cisneros-Franco, JM, Voss, P, Kang, MS, Thomas, ME, Côté, J, Ross, K et al.. PET Imaging of Perceptual Learning-Induced Changes in the Aged Rodent Cholinergic System. Front Neurosci. 2019;13 :1438. doi: 10.3389/fnins.2019.01438. PubMed PMID:32038142 PubMed Central PMC6985428.
  2. Ng, KP, Chiew, HJ, Rosa-Neto, P, Kandiah, N, Ismail, Z, Gauthier, S et al.. Brain Metabolic Dysfunction in Early Neuropsychiatric Symptoms of Dementia. Front Pharmacol. 2019;10 :1398. doi: 10.3389/fphar.2019.01398. PubMed PMID:31824321 PubMed Central PMC6882863.
  3. Ng, KP, Therriault, J, Kang, MS, Struyfs, H, Pascoal, TA, Mathotaarachchi, S et al.. Rasagiline, a monoamine oxidase B inhibitor, reduces in vivo [18F]THK5351 uptake in progressive supranuclear palsy. Neuroimage Clin. 2019;24 :102091. doi: 10.1016/j.nicl.2019.102091. PubMed PMID:31795034 PubMed Central PMC6889764.
  4. Sharafi, SM, Sylvestre, JP, Chevrefils, C, Soucy, JP, Beaulieu, S, Pascoal, TA et al.. Vascular retinal biomarkers improves the detection of the likely cerebral amyloid status from hyperspectral retinal images. Alzheimers Dement (N Y). 2019;5 :610-617. doi: 10.1016/j.trci.2019.09.006. PubMed PMID:31650017 PubMed Central PMC6804547.
  5. Hadoux, X, Hui, F, Lim, JKH, Masters, CL, Pébay, A, Chevalier, S et al.. Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease. Nat Commun. 2019;10 (1):4227. doi: 10.1038/s41467-019-12242-1. PubMed PMID:31530809 PubMed Central PMC6748929.
  6. Shin, J, Rowley, J, Chowdhury, R, Jolicoeur, P, Klein, D, Grova, C et al.. Inferior Longitudinal Fasciculus’ Role in Visual Processing and Language Comprehension: A Combined MEG-DTI Study. Front Neurosci. 2019;13 :875. doi: 10.3389/fnins.2019.00875. PubMed PMID:31507359 PubMed Central PMC6716060.
  7. Ryu, JC, Zimmer, ER, Rosa-Neto, P, Yoon, SO. Consequences of Metabolic Disruption in Alzheimer’s Disease Pathology. Neurotherapeutics. 2019;16 (3):600-610. doi: 10.1007/s13311-019-00755-y. PubMed PMID:31270743 PubMed Central PMC6694332.
  8. Cui, Y, Dai, S, Miao, Z, Zhong, Y, Liu, Y, Liu, L et al.. Reliability and Validity of the Chinese Version of the Mild Behavioral Impairment Checklist for Screening for Alzheimer’s Disease. J Alzheimers Dis. 2019;70 (3):747-756. doi: 10.3233/JAD-190113. PubMed PMID:31256131 .
  9. Therriault, J, Wang, S, Mathotaarachchi, S, Pascoal, TA, Parent, M, Beaudry, T et al.. Rostral-Caudal Hippocampal Functional Convergence Is Reduced Across the Alzheimer’s Disease Spectrum. Mol Neurobiol. 2019;56 (12):8336-8344. doi: 10.1007/s12035-019-01671-0. PubMed PMID:31230260 .
  10. Meyer, PF, Labonté, A, Rosa-Neto, P, Poirier, J, Breitner, JCS, PREVENT‐AD Research Group et al.. No apparent effect of naproxen on CSF markers of innate immune activation. Ann Clin Transl Neurol. 2019;6 (6):1127-1133. doi: 10.1002/acn3.788. PubMed PMID:31211178 PubMed Central PMC6562029.
  11. Miron, J, Picard, C, Lafaille-Magnan, MÉ, Savard, M, Labonté, A, Breitner, J et al.. Association of TLR4 with Alzheimer’s disease risk and presymptomatic biomarkers of inflammation. Alzheimers Dement. 2019;15 (7):951-960. doi: 10.1016/j.jalz.2019.03.012. PubMed PMID:31175027 .
  12. Pascoal, TA, Mathotaarachchi, S, Kang, MS, Mohaddes, S, Shin, M, Park, AY et al.. Aβ-induced vulnerability propagates via the brain’s default mode network. Nat Commun. 2019;10 (1):2353. doi: 10.1038/s41467-019-10217-w. PubMed PMID:31164641 PubMed Central PMC6547716.
  13. Liebsch, F, Kulic, L, Teunissen, C, Shobo, A, Ulku, I, Engelschalt, V et al.. Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression. Nat Commun. 2019;10 (1):2240. doi: 10.1038/s41467-019-10152-w. PubMed PMID:31110178 PubMed Central PMC6527709.
  14. Bailey, JJ, Kaiser, L, Lindner, S, Wüst, M, Thiel, A, Soucy, JP et al.. First-in-Human Brain Imaging of [18F]TRACK, a PET tracer for Tropomyosin Receptor Kinases. ACS Chem Neurosci. 2019;10 (6):2697-2702. doi: 10.1021/acschemneuro.9b00144. PubMed PMID:31017386 .
  15. Lleó, A, Alcolea, D, Martínez-Lage, P, Scheltens, P, Parnetti, L, Poirier, J et al.. Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer’s disease continuum in the BIOMARKAPD study. Alzheimers Dement. 2019;15 (6):742-753. doi: 10.1016/j.jalz.2019.01.015. PubMed PMID:30967340 .
  16. Meyer, PF, Tremblay-Mercier, J, Leoutsakos, J, Madjar, C, Lafaille-Maignan, MÉ, Savard, M et al.. INTREPAD: A randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease. Neurology. 2019;92 (18):e2070-e2080. doi: 10.1212/WNL.0000000000007232. PubMed PMID:30952794 PubMed Central PMC6512884.
  17. Miranda, A, Kang, MS, Blinder, S, Bouhachi, R, Soucy, JP, Aliaga-Aliaga, A et al.. PET imaging of freely moving interacting rats. Neuroimage. 2019;191 :560-567. doi: 10.1016/j.neuroimage.2019.02.064. PubMed PMID:30831313 .
  18. Liu, J, Wang, Q, Jing, D, Gao, R, Zhang, J, Cui, C et al.. Diagnostic Approach of Early-Onset Dementia with Negative Family History: Implications from Two Cases of Early-Onset Alzheimer’s Disease with De Novo PSEN1 Mutation. J Alzheimers Dis. 2019;68 (2):551-558. doi: 10.3233/JAD-181108. PubMed PMID:30814350 .
  19. Sheynin, Y, Chamoun, M, Baldwin, AS, Rosa-Neto, P, Hess, RF, Vaucher, E et al.. Cholinergic Potentiation Alters Perceptual Eye Dominance Plasticity Induced by a Few Hours of Monocular Patching in Adults. Front Neurosci. 2019;13 :22. doi: 10.3389/fnins.2019.00022. PubMed PMID:30766471 PubMed Central PMC6365463.
  20. Uribe, CF, Mathotaarachchi, S, Gaudet, V, Smith, KC, Rosa-Neto, P, Bénard, F et al.. Machine Learning in Nuclear Medicine: Part 1-Introduction. J Nucl Med. 2019;60 (4):451-458. doi: 10.2967/jnumed.118.223495. PubMed PMID:30733322 .
  21. Jiang, L, Oualkacha, K, Didelez, V, Ciampi, A, Rosa-Neto, P, Benedet, AL et al.. Constrained instruments and their application to Mendelian randomization with pleiotropy. Genet Epidemiol. 2019;43 (4):373-401. doi: 10.1002/gepi.22184. PubMed PMID:30635941 PubMed Central PMC6537099.
  22. Carter, SF, Herholz, K, Rosa-Neto, P, Pellerin, L, Nordberg, A, Zimmer, ER et al.. Astrocyte Biomarkers in Alzheimer’s Disease. Trends Mol Med. 2019;25 (2):77-95. doi: 10.1016/j.molmed.2018.11.006. PubMed PMID:30611668 .
  23. Schirrmacher, R, Bailey, JJ, Mossine, AV, Scott, PJH, Kaiser, L, Bartenstein, P et al.. Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging. Pharmaceuticals (Basel). 2019;12 (1):. doi: 10.3390/ph12010007. PubMed PMID:30609832 PubMed Central PMC6469173.
  24. Lam, J, DuBois, JM, Rowley, J, González-Otárula, KA, Soucy, JP, Massarweh, G et al.. In vivo metabotropic glutamate receptor type 5 abnormalities localize the epileptogenic zone in mesial temporal lobe epilepsy. Ann Neurol. 2019;85 (2):218-228. doi: 10.1002/ana.25404. PubMed PMID:30597619 .
  25. Hopewell, R, Ross, K, Kostikov, A, Pascoal, TA, Alberti, T, Lacatus-Samoila, M et al.. A simplified radiosynthesis of [18 F]MK-6240 for tau PET imaging. J Labelled Comp Radiopharm. 2019;62 (2):109-114. doi: 10.1002/jlcr.3695. PubMed PMID:30426529 .
  26. Schilling, LP, Pascoal, TA, Zimmer, ER, Mathotaarachchi, S, Shin, M, de Mello Rieder, CR et al.. Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer’s Dementia. Mol Neurobiol. 2019;56 (7):4916-4924. doi: 10.1007/s12035-018-1405-1. PubMed PMID:30414086 .


  1. Zhang, H, Ng, KP, Therriault, J, Kang, MS, Pascoal, TA, Rosa-Neto, P et al.. Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease. Transl Neurodegener. 2018;7 :23. doi: 10.1186/s40035-018-0127-7. PubMed PMID:30311914 PubMed Central PMC6161434.
  2. Ng, KP, Chiew, HJ, Lim, L, Rosa-Neto, P, Kandiah, N, Gauthier, S et al.. The influence of language and culture on cognitive assessment tools in the diagnosis of early cognitive impairment and dementia. Expert Rev Neurother. 2018;18 (11):859-869. doi: 10.1080/14737175.2018.1532792. PubMed PMID:30286681 .
  3. Zhang, H, Therriault, J, Kang, MS, Ng, KP, Pascoal, TA, Rosa-Neto, P et al.. Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer’s disease. Alzheimers Res Ther. 2018;10 (1):80. doi: 10.1186/s13195-018-0407-6. PubMed PMID:30115118 PubMed Central PMC6097333.
  4. Gauthier, S, Herrmann, N, Rosa-Neto, P. Optimal use of cholinergic drugs in Alzheimer’s disease. Brain. 2018;141 (9):e68. doi: 10.1093/brain/awy204. PubMed PMID:30084978 .
  5. Pascoal, TA, Shin, M, Kang, MS, Chamoun, M, Chartrand, D, Mathotaarachchi, S et al.. In vivo quantification of neurofibrillary tangles with [18F]MK-6240. Alzheimers Res Ther. 2018;10 (1):74. doi: 10.1186/s13195-018-0402-y. PubMed PMID:30064520 PubMed Central PMC6069775.
  6. Guadagno, A, Kang, MS, Devenyi, GA, Mathieu, AP, Rosa-Neto, P, Chakravarty, M et al.. Reduced resting-state functional connectivity of the basolateral amygdala to the medial prefrontal cortex in preweaning rats exposed to chronic early-life stress. Brain Struct Funct. 2018;223 (8):3711-3729. doi: 10.1007/s00429-018-1720-3. PubMed PMID:30032360 .
  7. Zukotynski, K, Kuo, PH, Mikulis, D, Rosa-Neto, P, Strafella, AP, Subramaniam, RM et al.. PET/CT of Dementia. AJR Am J Roentgenol. 2018;211 (2):246-259. doi: 10.2214/AJR.18.19822. PubMed PMID:29949415 .
  8. Smart, K, Cox, SML, Nagano-Saito, A, Rosa-Neto, P, Leyton, M, Benkelfat, C et al.. Test-retest variability of [11 C]ABP688 estimates of metabotropic glutamate receptor subtype 5 availability in humans. Synapse. 2018;72 (9):e22041. doi: 10.1002/syn.22041. PubMed PMID:29935121 .
  9. Gauthier, S, Zhang, H, Ng, KP, Pascoal, TA, Rosa-Neto, P. Impact of the biological definition of Alzheimer’s disease using amyloid, tau and neurodegeneration (ATN): what about the role of vascular changes, inflammation, Lewy body pathology?. Transl Neurodegener. 2018;7 :12. doi: 10.1186/s40035-018-0117-9. PubMed PMID:29876101 PubMed Central PMC5977549.
  10. Meyer, PF, Savard, M, Poirier, J, Labonté, A, Rosa-Neto, P, Weitz, TM et al.. Bi-directional Association of Cerebrospinal Fluid Immune Markers with Stage of Alzheimer’s Disease Pathogenesis. J Alzheimers Dis. 2018;63 (2):577-590. doi: 10.3233/JAD-170887. PubMed PMID:29660934 PubMed Central PMC5929310.
  11. Gauthier, S, Ng, KP, Pascoal, TA, Zhang, H, Rosa-Neto, P. Targeting Alzheimer’s Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment. J Alzheimers Dis. 2018;64 (s1):S23-S31. doi: 10.3233/JAD-179924. PubMed PMID:29504543 PubMed Central PMC6004905.
  12. Villeneuve, S, Vogel, JW, Gonneaud, J, Pichet Binette, A, Rosa-Neto, P, Gauthier, S et al.. Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease. JAMA Neurol. 2018;75 (5):608-619. doi: 10.1001/jamaneurol.2017.5135. PubMed PMID:29482212 PubMed Central PMC5885216.
  13. Benedet, AL, Yu, L, Labbe, A, Mathotaarachchi, S, Pascoal, TA, Shin, M et al.CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem. Neurol Genet. 2018;4 (1):e216. doi: 10.1212/NXG.0000000000000216. PubMed PMID:29473050 PubMed Central PMC5820598.
  14. Therriault, J, Ng, KP, Pascoal, TA, Mathotaarachchi, S, Kang, MS, Struyfs, H et al.. Anosognosia predicts default mode network hypometabolism and clinical progression to dementia. Neurology. 2018;90 (11):e932-e939. doi: 10.1212/WNL.0000000000005120. PubMed PMID:29444971 PubMed Central PMC5858945.
  15. Pascoal, TA, Mathotaarachchi, S, Shin, M, Park, AY, Mohades, S, Benedet, AL et al.. Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2018;45 (6):1021-1030. doi: 10.1007/s00259-018-3933-3. PubMed PMID:29396637 PubMed Central PMC5915512.
  16. Henriques, AD, Benedet, AL, Camargos, EF, Rosa-Neto, P, Nóbrega, OT. Fluid and imaging biomarkers for Alzheimer’s disease: Where we stand and where to head to. Exp Gerontol. 2018;107 :169-177. doi: 10.1016/j.exger.2018.01.002. PubMed PMID:29307736 PubMed Central PMC5951730.
  17. Bernard-Gauthier, V, Mossine, AV, Mahringer, A, Aliaga, A, Bailey, JJ, Shao, X et al.. Identification of [18F]TRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging. J Med Chem. 2018;61 (4):1737-1743. doi: 10.1021/acs.jmedchem.7b01607. PubMed PMID:29257860 .
  18. Tardif, CL, Devenyi, GA, Amaral, RSC, Pelleieux, S, Poirier, J, Rosa-Neto, P et al.. Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer’s disease. Hum Brain Mapp. 2018;39 (2):971-984. doi: 10.1002/hbm.23897. PubMed PMID:29164798 PubMed Central PMC6866392.
  19. Li, X, Ba, M, Ng, KP, Mathotaarachchi, S, Pascoal, TA, Rosa-Neto, P et al.. Characterizing biomarker features of cognitively normal individuals with ventriculomegaly. Alzheimers Dement (Amst). 2018;10 :12-21. doi: 10.1016/j.dadm.2017.08.001. PubMed PMID:29159265 PubMed Central PMC5678356.


  1. Parent, MJ, Zimmer, ER, Shin, M, Kang, MS, Fonov, VS, Mathieu, A et al.. Multimodal Imaging in Rat Model Recapitulates Alzheimer’s Disease Biomarkers Abnormalities. J Neurosci. 2017;37 (50):12263-12271. doi: 10.1523/JNEUROSCI.1346-17.2017. PubMed PMID:29097597 PubMed Central PMC5729194.
  2. Gauthier, S, Ng, KP, Pascoal, TA, Mathotaarachchi, S, Chung, CO, Benedetti, AL et al.. Author response: Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017;89 (18):1931. doi: 10.1212/WNL.0000000000004593. PubMed PMID:29084927 .
  3. Ba, M, Li, X, Ng, KP, Pascoal, TA, Mathotaarachchi, S, Rosa-Neto, P et al.. The prevalence and biomarkers’ characteristic of rapidly progressive Alzheimer’s disease from the Alzheimer’s Disease Neuroimaging Initiative database. Alzheimers Dement (N Y). 2017;3 (1):107-113. doi: 10.1016/j.trci.2016.12.005. PubMed PMID:29067322 PubMed Central PMC5651370.
  4. Tuwaig, M, Savard, M, Jutras, B, Poirier, J, Collins, DL, Rosa-Neto, P et al.. Deficit in Central Auditory Processing as a Biomarker of Pre-Clinical Alzheimer’s Disease. J Alzheimers Dis. 2017;60 (4):1589-1600. doi: 10.3233/JAD-170545. PubMed PMID:28984583 PubMed Central PMC5757649.
  5. Aghourian, M, Legault-Denis, C, Soucy, JP, Rosa-Neto, P, Gauthier, S, Kostikov, A et al.. Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV. Mol Psychiatry. 2017;22 (11):1531-1538. doi: 10.1038/mp.2017.183. PubMed PMID:28894304 .
  6. Mathotaarachchi, S, Pascoal, TA, Shin, M, Benedet, AL, Kang, MS, Beaudry, T et al.. Identifying incipient dementia individuals using machine learning and amyloid imaging. Neurobiol Aging. 2017;59 :80-90. doi: 10.1016/j.neurobiolaging.2017.06.027. PubMed PMID:28756942 .
  7. Bernard-Gauthier, V, Bailey, JJ, Mossine, AV, Lindner, S, Vomacka, L, Aliaga, A et al.. A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human. J Med Chem. 2017;60 (16):6897-6910. doi: 10.1021/acs.jmedchem.7b00396. PubMed PMID:28696690 .
  8. Lafaille-Magnan, ME, Poirier, J, Etienne, P, Tremblay-Mercier, J, Frenette, J, Rosa-Neto, P et al.. Odor identification as a biomarker of preclinical AD in older adults at risk. Neurology. 2017;89 (4):327-335. doi: 10.1212/WNL.0000000000004159. PubMed PMID:28659431 PubMed Central PMC5574678.
  9. Engelborghs, S, Niemantsverdriet, E, Struyfs, H, Blennow, K, Brouns, R, Comabella, M et al.. Consensus guidelines for lumbar puncture in patients with neurological diseases. Alzheimers Dement (Amst). 2017;8 :111-126. doi: 10.1016/j.dadm.2017.04.007. PubMed PMID:28603768 PubMed Central PMC5454085.
  10. Dadar, M, Pascoal, TA, Manitsirikul, S, Misquitta, K, Fonov, VS, Tartaglia, MC et al.. Validation of a Regression Technique for Segmentation of White Matter Hyperintensities in Alzheimer’s Disease. IEEE Trans Med Imaging. 2017;36 (8):1758-1768. doi: 10.1109/TMI.2017.2693978. PubMed PMID:28422655 .
  11. Ng, KP, Pascoal, TA, Mathotaarachchi, S, Chung, CO, Benedet, AL, Shin, M et al.. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017;88 (19):1814-1821. doi: 10.1212/WNL.0000000000003916. PubMed PMID:28404803 PubMed Central PMC5419982.
  12. Chamoun, M, Huppé-Gourgues, F, Legault, I, Rosa-Neto, P, Dumbrava, D, Faubert, J et al.. Cholinergic Potentiation Improves Perceptual-Cognitive Training of Healthy Young Adults in Three Dimensional Multiple Object Tracking. Front Hum Neurosci. 2017;11 :128. doi: 10.3389/fnhum.2017.00128. PubMed PMID:28377707 PubMed Central PMC5359296.
  13. Ng, KP, Pascoal, TA, Mathotaarachchi, S, Therriault, J, Kang, MS, Shin, M et al.. Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain. Alzheimers Res Ther. 2017;9 (1):25. doi: 10.1186/s13195-017-0253-y. PubMed PMID:28359327 PubMed Central PMC5374697.
  14. Zimmer, ER, Parent, MJ, Souza, DG, Leuzy, A, Lecrux, C, Kim, HI et al.. [18F]FDG PET signal is driven by astroglial glutamate transport. Nat Neurosci. 2017;20 (3):393-395. doi: 10.1038/nn.4492. PubMed PMID:28135241 PubMed Central PMC5378483.
  15. Pascoal, TA, Mathotaarachchi, S, Shin, M, Benedet, AL, Mohades, S, Wang, S et al.. Synergistic interaction between amyloid and tau predicts the progression to dementia. Alzheimers Dement. 2017;13 (6):644-653. doi: 10.1016/j.jalz.2016.11.005. PubMed PMID:28024995 .
  16. Pascoal, TA, Mathotaarachchi, S, Mohades, S, Benedet, AL, Chung, CO, Shin, M et al.. Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease. Mol Psychiatry. 2017;22 (2):306-311. doi: 10.1038/mp.2016.37. PubMed PMID:27021814 PubMed Central PMC5262471.


  1. Tam, A, Dansereau, C, Badhwar, A, Orban, P, Belleville, S, Chertkow, H et al.. A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment. Data Brief. 2016;9 :1122-1129. doi: 10.1016/j.dib.2016.11.036. PubMed PMID:27924300 PubMed Central PMC5128734.
  2. Ba, M, Kong, M, Li, X, Ng, KP, Rosa-Neto, P, Gauthier, S et al.. Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer’s disease?. Transl Neurodegener. 2016;5 :20. doi: 10.1186/s40035-016-0067-z. PubMed PMID:27891223 PubMed Central PMC5112745.
  3. Mechling, AE, Arefin, T, Lee, HL, Bienert, T, Reisert, M, Ben Hamida, S et al.. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome. Proc Natl Acad Sci U S A. 2016;113 (41):11603-11608. doi: 10.1073/pnas.1601640113. PubMed PMID:27671662 PubMed Central PMC5068324.
  4. DuBois, JM, Rousset, OG, Guiot, MC, Hall, JA, Reader, AJ, Soucy, JP et al.. Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging. Cereb Cortex. 2016;26 (11):4170-4179. doi: 10.1093/cercor/bhw249. PubMed PMID:27578494 PubMed Central PMC5066831.
  5. Gibon, J, Kang, MS, Aliaga, A, Sharif, B, Rosa-Neto, P, Séguéla, P et al.. Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile. Bioorg Med Chem. 2016;24 (19):4759-4765. doi: 10.1016/j.bmc.2016.08.020. PubMed PMID:27567078 .
  6. Mathotaarachchi, S, Wang, S, Shin, M, Pascoal, TA, Benedet, AL, Kang, MS et al.. VoxelStats: A MATLAB Package for Multi-Modal Voxel-Wise Brain Image Analysis. Front Neuroinform. 2016;10 :20. doi: 10.3389/fninf.2016.00020. PubMed PMID:27378902 PubMed Central PMC4908129.
  7. Cho, J, Kwon, DH, Kim, RG, Song, H, Rosa-Neto, P, Lee, MC et al.. Remodeling of Neuronal Circuits After Reach Training in Chronic Capsular Stroke. Neurorehabil Neural Repair. 2016;30 (10):941-950. doi: 10.1177/1545968316650282. PubMed PMID:27198184 .
  8. Gauthier, S, Rosa-Neto, P, Kass, JS. Ethical Considerations for the Use of Next-Generation Alzheimer Drugs in Symptomatic and At-Risk Patients. Continuum (Minneap Minn). 2016;22 (2 Dementia):615-8. doi: 10.1212/CON.0000000000000306. PubMed PMID:27042911 PubMed Central PMC5390936.
  9. Schilling, LP, Zimmer, ER, Shin, M, Leuzy, A, Pascoal, TA, Benedet, AL et al.. Imaging Alzheimer’s disease pathophysiology with PET. Dement Neuropsychol. ;10 (2):79-90. doi: 10.1590/S1980-5764-2016DN1002003. PubMed PMID:29213438 PubMed Central PMC5642398.
  10. Pascoal, TA, Mathotaarachchi, S, Mohades, S, Benedet, AL, Chung, CO, Shin, M et al.. Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease. Mol Psychiatry. 2017;22 (2):306-311. doi: 10.1038/mp.2016.37. PubMed PMID:27021814 PubMed Central PMC5262471.
  11. Laforce, R, Rosa-Neto, P, Soucy, JP, Rabinovici, GD, Dubois, B, Gauthier, S et al.. Canadian Consensus Guidelines on Use of Amyloid Imaging in Canada: Update and Future Directions from the Specialized Task Force on Amyloid imaging in Canada. Can J Neurol Sci. 2016;43 (4):503-12. doi: 10.1017/cjn.2015.401. PubMed PMID:26916179 .
  12. Tomaszewski, S, Gauthier, S, Wimo, A, Rosa-Neto, P. Combination Therapy of Anti-Tau and Anti-Amyloid Drugs for Disease Modification in Early-stage Alzheimer’s Disease: Socio-economic Considerations Modeled on Treatments for Tuberculosis, HIV/AIDS and Breast Cancer. J Prev Alzheimers Dis. 2016;3 (3):164-172. doi: 10.14283/jpad.2015.85. PubMed PMID:29205255 .
  13. Kim, RG, Cho, J, Ree, J, Kim, HS, Rosa-Neto, P, Kim, JM et al.. Sensory-parietal cortical stimulation improves motor recovery in severe capsular infarct. J Cereb Blood Flow Metab. 2016;36 (12):2211-2222. doi: 10.1177/0271678X15606136. PubMed PMID:26661148 PubMed Central PMC5363658.
  14. DuBois, JM, Rousset, OG, Rowley, J, Porras-Betancourt, M, Reader, AJ, Labbe, A et al.. Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET. Eur J Nucl Med Mol Imaging. 2016;43 (1):152-162. doi: 10.1007/s00259-015-3167-6. PubMed PMID:26290423 .
  15. Leuzy, A, Zimmer, ER, Dubois, J, Pruessner, J, Cooperman, C, Soucy, JP et al.. In vivo characterization of metabotropic glutamate receptor type 5 abnormalities in behavioral variant FTD. Brain Struct Funct. 2016;221 (3):1387-402. doi: 10.1007/s00429-014-0978-3. PubMed PMID:25596865 .


  1. Tam, A, Dansereau, C, Badhwar, A, Orban, P, Belleville, S, Chertkow, H et al.. Common Effects of Amnestic Mild Cognitive Impairment on Resting-State Connectivity Across Four Independent Studies. Front Aging Neurosci. 2015;7 :242. doi: 10.3389/fnagi.2015.00242. PubMed PMID:26733866 PubMed Central PMC4689788.
  2. Benedet, AL, Labbe, A, Lemay, P, Zimmer, ER, Pascoal, TA, Leuzy, A et al.. Epistasis analysis links immune cascades and cerebral amyloidosis. J Neuroinflammation. 2015;12 :227. doi: 10.1186/s12974-015-0436-z. PubMed PMID:26626881 PubMed Central PMC4666175.
  3. Orban, P, Madjar, C, Savard, M, Dansereau, C, Tam, A, Das, S et al.. Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer’s disease. Sci Data. 2015;2 :150043. doi: 10.1038/sdata.2015.43. PubMed PMID:26504522 PubMed Central PMC4603392.
  4. Zimmer, ER, Parent, MJ, Leuzy, A, Aliaga, A, Aliaga, A, Moquin, L et al.. Imaging in vivo glutamate fluctuations with [(11)C]ABP688: a GLT-1 challenge with ceftriaxone. J Cereb Blood Flow Metab. 2015;35 (7):1169-74. doi: 10.1038/jcbfm.2015.35. PubMed PMID:25806702 PubMed Central PMC4640271.
  5. Bernard-Gauthier, V, Aliaga, A, Aliaga, A, Boudjemeline, M, Hopewell, R, Kostikov, A et al.. Syntheses and evaluation of carbon-11- and fluorine-18-radiolabeled pan-tropomyosin receptor kinase (Trk) inhibitors: exploration of the 4-aza-2-oxindole scaffold as Trk PET imaging agents. ACS Chem Neurosci. 2015;6 (2):260-76. doi: 10.1021/cn500193f. PubMed PMID:25350780 .
  6. Cyr, M, Parent, MJ, Mechawar, N, Rosa-Neto, P, Soucy, JP, Clark, SD et al.. Deficit in sustained attention following selective cholinergic lesion of the pedunculopontine tegmental nucleus in rat, as measured with both post-mortem immunocytochemistry and in vivo PET imaging with [¹⁸F]fluoroethoxybenzovesamicol. Behav Brain Res. 2015;278 :107-14. doi: 10.1016/j.bbr.2014.09.021. PubMed PMID:25257103 .


  1. Zimmer, ER, Leuzy, A, Gauthier, S, Rosa-Neto, P. Developments in Tau PET Imaging. Can J Neurol Sci. 2014;41 (5):547-53. doi: 10.1017/cjn.2014.15. PubMed PMID:25424608 .
  2. Zimmer, ER, Parent, MJ, Cuello, AC, Gauthier, S, Rosa-Neto, P. MicroPET imaging and transgenic models: a blueprint for Alzheimer’s disease clinical research. Trends Neurosci. 2014;37 (11):629-41. doi: 10.1016/j.tins.2014.07.002. PubMed PMID:25151336 .
  3. Zimmer, ER, Leuzy, A, Benedet, AL, Breitner, J, Gauthier, S, Rosa-Neto, P et al.. Tracking neuroinflammation in Alzheimer’s disease: the role of positron emission tomography imaging. J Neuroinflammation. 2014;11 :120. doi: 10.1186/1742-2094-11-120. PubMed PMID:25005532 PubMed Central PMC4099095.
  4. Leuzy, A, Zimmer, ER, Heurling, K, Rosa-Neto, P, Gauthier, S. Use of amyloid PET across the spectrum of Alzheimer’s disease: clinical utility and associated ethical issues. Amyloid. 2014;21 (3):143-8. doi: 10.3109/13506129.2014.926267. PubMed PMID:24919109 .
  5. Ongali, B, Nicolakakis, N, Tong, XK, Aboulkassim, T, Papadopoulos, P, Rosa-Neto, P et al.. Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model. Neurobiol Dis. 2014;68 :126-36. doi: 10.1016/j.nbd.2014.04.018. PubMed PMID:24807206 .
  6. Milella, MS, Marengo, L, Larcher, K, Fotros, A, Dagher, A, Rosa-Neto, P et al.. Limbic system mGluR5 availability in cocaine dependent subjects: a high-resolution PET [(11)C]ABP688 study. Neuroimage. 2014;98 :195-202. doi: 10.1016/j.neuroimage.2014.04.061. PubMed PMID:24795154 .
  7. Zimmer, ER, Leuzy, A, Bhat, V, Gauthier, S, Rosa-Neto, P. In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals. Transl Neurodegener. 2014;3 (1):6. doi: 10.1186/2047-9158-3-6. PubMed PMID:24628994 PubMed Central PMC3995516.
  8. Wu, L, Soder, RB, Schoemaker, D, Carbonnell, F, Sziklas, V, Rowley, J et al.. Resting state executive control network adaptations in amnestic mild cognitive impairment. J Alzheimers Dis. 2014;40 (4):993-1004. doi: 10.3233/JAD-131574. PubMed PMID:24583406 .
  9. Leuzy, A, Zimmer, ER, Bhat, V, Rosa-Neto, P, Gauthier, S. Imaging biomarkers for amyloid: a new generation of probes and what lies ahead. Int Psychogeriatr. 2014;26 (5):703-7. doi: 10.1017/S1041610214000118. PubMed PMID:24524685 .
  10. Cyr, M, Parent, MJ, Mechawar, N, Rosa-Neto, P, Soucy, JP, Aliaga, A et al.. PET imaging with [¹⁸F]fluoroethoxybenzovesamicol ([¹⁸F]FEOBV) following selective lesion of cholinergic pedunculopontine tegmental neurons in rat. Nucl Med Biol. 2014;41 (1):96-101. doi: 10.1016/j.nucmedbio.2013.10.004. PubMed PMID:24267056 .
  11. Gauthier, S, Leuzy, A, Rosa-Neto, P. How can we improve transfer of outcomes from randomized clinical trials to clinical practice with disease-modifying drugs in Alzheimer’s disease?. Neurodegener Dis. 2014;13 (2-3):197-9. doi: 10.1159/000353748. PubMed PMID:23942173 .


  1. Rosa-Neto, P, Hsiung, GY, Masellis, M, CCDTD4 participants. Fluid biomarkers for diagnosing dementia: rationale and the Canadian Consensus on Diagnosis and Treatment of Dementia recommendations for Canadian physicians. Alzheimers Res Ther. 2013;5 (Suppl 1):S8. doi: 10.1186/alzrt223. PubMed PMID:24565514 PubMed Central PMC3980280.
  2. Burhan, AM, Bartha, R, Bocti, C, Borrie, M, Laforce, R, Rosa-Neto, P et al.. Role of emerging neuroimaging modalities in patients with cognitive impairment: a review from the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012. Alzheimers Res Ther. 2013;5 (Suppl 1):S4. doi: 10.1186/alzrt200. PubMed PMID:24565285 PubMed Central PMC3981649.
  3. Soucy, JP, Bartha, R, Bocti, C, Borrie, M, Burhan, AM, Laforce, R et al.. Clinical applications of neuroimaging in patients with Alzheimer’s disease: a review from the Fourth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012. Alzheimers Res Ther. 2013;5 (Suppl 1):S3. doi: 10.1186/alzrt199. PubMed PMID:24565260 PubMed Central PMC3980588.
  4. Parent, MJ, Bedard, MA, Aliaga, A, Minuzzi, L, Mechawar, N, Soucy, JP et al.. Cholinergic Depletion in Alzheimer’s Disease Shown by [ (18) F]FEOBV Autoradiography. Int J Mol Imaging. 2013;2013 :205045. doi: 10.1155/2013/205045. PubMed PMID:24324884 PubMed Central PMC3844185.
  5. Bernard-Gauthier, V, Boudjemeline, M, Rosa-Neto, P, Thiel, A, Schirrmacher, R. Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: radiosynthesis and evaluation of 2-(4-[(18)F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-(11)C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one. Bioorg Med Chem. 2013;21 (24):7816-29. doi: 10.1016/j.bmc.2013.10.012. PubMed PMID:24183588 .
  6. Gauthier, S, Rosa-Neto, P. Dementia: Disclosure of results to participants in dementia research. Nat Rev Neurol. 2013;9 (11):608-9. doi: 10.1038/nrneurol.2013.213. PubMed PMID:24145370 .
  7. Parent, MJ, Cyr, M, Aliaga, A, Kostikov, A, Schirrmacher, E, Soucy, JP et al.. Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase immunochemistry. EJNMMI Res. 2013;3 (1):70. doi: 10.1186/2191-219X-3-70. PubMed PMID:24103360 PubMed Central PMC3852759.
  8. Rowley, J, Fonov, V, Wu, O, Eskildsen, SF, Schoemaker, D, Wu, L et al.. White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and Alzheimer’s disease. PLoS One. 2013;8 (9):e74776. doi: 10.1371/journal.pone.0074776. PubMed PMID:24086371 PubMed Central PMC3785512.
  9. Papadopoulos, P, Rosa-Neto, P, Rochford, J, Hamel, E. Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer’s disease with combined amyloid-β and cerebrovascular pathology. PLoS One. 2013;8 (7):e68612. doi: 10.1371/journal.pone.0068612. PubMed PMID:23874687 PubMed Central PMC3715495.
  10. Kandratavicius, L, Rosa-Neto, P, Monteiro, MR, Guiot, MC, Assirati, JA Jr, Carlotti, CG Jr et al.. Distinct increased metabotropic glutamate receptor type 5 (mGluR5) in temporal lobe epilepsy with and without hippocampal sclerosis. Hippocampus. 2013;23 (12):1212-30. doi: 10.1002/hipo.22160. PubMed PMID:23804486 PubMed Central PMC4165311.
  11. Gauthier, S, Leuzy, A, Racine, E, Rosa-Neto, P. Diagnosis and management of Alzheimer’s disease: past, present and future ethical issues. Prog Neurobiol. 2013;110 :102-13. doi: 10.1016/j.pneurobio.2013.01.003. PubMed PMID:23578568 .
  12. Zhao, L, Boucher, M, Rosa-Neto, P, Evans, AC. Impact of scale space search on age- and gender-related changes in MRI-based cortical morphometry. Hum Brain Mapp. 2013;34 (9):2113-28. doi: 10.1002/hbm.22050. PubMed PMID:22422546 PubMed Central PMC6870203.


  1. Gauthier, S, Patterson, C, Chertkow, H, Gordon, M, Herrmann, N, Rockwood, K et al.. Recommendations of the 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD4). Can Geriatr J. 2012;15 (4):120-6. doi: 10.5770/cgj.15.49. PubMed PMID:23259025 PubMed Central PMC3516356.
  2. Gauthier, S, Patterson, C, Chertkow, H, Gordon, M, Herrmann, N, Rockwood, K et al.. 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia. Can J Neurol Sci. 2012;39 (6 Suppl 5):S1-8. doi: 10.1017/s0317167100015183. PubMed PMID:23073396 .
  3. Gauthier, S, Wu, L, Rosa-Neto, P, Jia, J. Prevention strategies for Alzheimer’s disease. Transl Neurodegener. 2012;1 (1):13. doi: 10.1186/2047-9158-1-13. PubMed PMID:23210473 PubMed Central PMC3514088.
  4. Wu, L, Rowley, J, Mohades, S, Leuzy, A, Dauar, MT, Shin, M et al.. Dissociation between brain amyloid deposition and metabolism in early mild cognitive impairment. PLoS One. 2012;7 (10):e47905. doi: 10.1371/journal.pone.0047905. PubMed PMID:23112868 PubMed Central PMC3480449.
  5. Wu, L, Rosa-Neto, P, Hsiung, GY, Sadovnick, AD, Masellis, M, Black, SE et al.. Early-onset familial Alzheimer’s disease (EOFAD). Can J Neurol Sci. 2012;39 (4):436-45. doi: 10.1017/s0317167100013949. PubMed PMID:22728850 .
  6. Parent, M, Bedard, MA, Aliaga, A, Soucy, JP, Landry St-Pierre, E, Cyr, M et al.. PET imaging of cholinergic deficits in rats using [18F]fluoroethoxybenzovesamicol ([18F]FEOBV). Neuroimage. 2012;62 (1):555-61. doi: 10.1016/j.neuroimage.2012.04.032. PubMed PMID:22555071 .
  7. Tong, XK, Lecrux, C, Rosa-Neto, P, Hamel, E. Age-dependent rescue by simvastatin of Alzheimer’s disease cerebrovascular and memory deficits. J Neurosci. 2012;32 (14):4705-15. doi: 10.1523/JNEUROSCI.0169-12.2012. PubMed PMID:22492027 PubMed Central PMC6620905.
  8. Kovačević, T, Skelin, I, Minuzzi, L, Rosa-Neto, P, Diksic, M. Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: an autoradiographic study. Brain Res Bull. 2012;87 (4-5):406-12. doi: 10.1016/j.brainresbull.2012.01.010. PubMed PMID:22310150 PubMed Central PMC3641045.
  9. Elmenhorst, D, Aliaga, A, Bauer, A, Rosa-Neto, P. Test-retest stability of cerebral mGluR₅ quantification using [¹¹C]ABP688 and positron emission tomography in rats. Synapse. 2012;66 (6):552-60. doi: 10.1002/syn.21542. PubMed PMID:22290765 .


  1. Berney, A, Leyton, M, Gravel, P, Sibon, I, Sookman, D, Rosa Neto, P et al.. Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorder. Arch Gen Psychiatry. 2011;68 (7):732-41. doi: 10.1001/archgenpsychiatry.2011.16. PubMed PMID:21383250 PubMed Central PMC3677917.
  2. Chen, ZJ, He, Y, Rosa-Neto, P, Gong, G, Evans, AC. Age-related alterations in the modular organization of structural cortical network by using cortical thickness from MRI. Neuroimage. 2011;56 (1):235-45. doi: 10.1016/j.neuroimage.2011.01.010. PubMed PMID:21238595 .
  3. Oishi, K, Huang, H, Yoshioka, T, Ying, SH, Zee, DS, Zilles, K et al.. Superficially located white matter structures commonly seen in the human and the macaque brain with diffusion tensor imaging. Brain Connect. 2011;1 (1):37-47. doi: 10.1089/brain.2011.0005. PubMed PMID:22432953 PubMed Central PMC3569096.
  4. Nicolakakis, N, Aboulkassim, T, Aliaga, A, Tong, XK, Rosa-Neto, P, Hamel, E et al.. Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone. J Cereb Blood Flow Metab. 2011;31 (1):200-11. doi: 10.1038/jcbfm.2010.78. PubMed PMID:20571524 PubMed Central PMC3049484.


  1. Ongali, B, Nicolakakis, N, Lecrux, C, Aboulkassim, T, Rosa-Neto, P, Papadopoulos, P et al.. Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer’s disease. Am J Pathol. 2010;177 (6):3071-80. doi: 10.2353/ajpath.2010.100339. PubMed PMID:21088218 PubMed Central PMC2993264.
  2. Bertomeu, T, Zvereff, V, Ibrahim, A, Zehntner, SP, Aliaga, A, Rosa-Neto, P et al.. TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation. Biochem Pharmacol. 2010;80 (10):1572-9. doi: 10.1016/j.bcp.2010.07.018. PubMed PMID:20655882 .
  3. Verhaeghe, J, Gravel, P, Mio, R, Fukasawa, R, Rosa-Neto, P, Soucy, JP et al.. Motion compensation for fully 4D PET reconstruction using PET superset data. Phys Med Biol. 2010;55 (14):4063-82. doi: 10.1088/0031-9155/55/14/008. PubMed PMID:20601774 .
  4. Zhang, Y, Zhang, J, Oishi, K, Faria, AV, Jiang, H, Li, X et al.. Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy. Neuroimage. 2010;52 (4):1289-301. doi: 10.1016/j.neuroimage.2010.05.049. PubMed PMID:20570617 PubMed Central PMC2910162.
  5. Elmenhorst, D, Minuzzi, L, Aliaga, A, Rowley, J, Massarweh, G, Diksic, M et al.. In vivo and in vitro validation of reference tissue models for the mGluR(5) ligand [(11)C]ABP688. J Cereb Blood Flow Metab. 2010;30 (8):1538-49. doi: 10.1038/jcbfm.2010.65. PubMed PMID:20531460 PubMed Central PMC2949244.
  6. Bellec, P, Rosa-Neto, P, Lyttelton, OC, Benali, H, Evans, AC. Multi-level bootstrap analysis of stable clusters in resting-state fMRI. Neuroimage. 2010;51 (3):1126-39. doi: 10.1016/j.neuroimage.2010.02.082. PubMed PMID:20226257 .
  7. la Fougère, C, Böning, G, Bartmann, H, Wängler, B, Nowak, S, Just, T et al.. Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar. Neuroimage. 2010;49 (2):1406-15. doi: 10.1016/j.neuroimage.2009.09.048. PubMed PMID:19796699 .


  1. Gong, G, Rosa-Neto, P, Carbonell, F, Chen, ZJ, He, Y, Evans, AC et al.. Age- and gender-related differences in the cortical anatomical network. J Neurosci. 2009;29 (50):15684-93. doi: 10.1523/JNEUROSCI.2308-09.2009. PubMed PMID:20016083 PubMed Central PMC2831804.
  2. Massarweh, G, Kovacevic, M, Rosa-Neto, P, Evans, AC, Diksic, M, Schirrmacher, R et al.. Time-efficient and convenient synthesis of [(18)F]altanserin for human PET imaging by a new work-up procedure. Appl Radiat Isot. 2009;67 (11):2040-3. doi: 10.1016/j.apradiso.2009.07.020. PubMed PMID:19692252 .
  3. Chakravarty, MM, Broadbent, S, Rosa-Neto, P, Lambert, CM, Collins, DL. Design, construction, and validation of an MRI-compatible vibrotactile stimulator intended for clinical use. J Neurosci Methods. 2009;184 (1):129-35. doi: 10.1016/j.jneumeth.2009.07.018. PubMed PMID:19631690 .
  4. Rosa-Neto, P, Wängler, B, Iovkova, L, Boening, G, Reader, A, Jurkschat, K et al.. [18F]SiFA-isothiocyanate: a new highly effective radioactive labeling agent for lysine-containing proteins. Chembiochem. 2009;10 (8):1321-4. doi: 10.1002/cbic.200900132. PubMed PMID:19422010 .
  5. Oishi, K, Faria, A, Jiang, H, Li, X, Akhter, K, Zhang, J et al.. Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer’s disease participants. Neuroimage. 2009;46 (2):486-99. doi: 10.1016/j.neuroimage.2009.01.002. PubMed PMID:19385016 PubMed Central PMC2885858.
  6. Aznavour, N, Benkelfat, C, Gravel, P, Aliaga, A, Rosa-Neto, P, Bedell, B et al.. MicroPET imaging of 5-HT 1A receptors in rat brain: a test-retest [18F]MPPF study. Eur J Nucl Med Mol Imaging. 2009;36 (1):53-62. doi: 10.1007/s00259-008-0891-1. PubMed PMID:18704404 .
  7. Chakravarty, MM, Rosa-Neto, P, Broadbent, S, Evans, AC, Collins, DL. Robust S1, S2, and thalamic activations in individual subjects with vibrotactile stimulation at 1.5 and 3.0 T. Hum Brain Mapp. 2009;30 (4):1328-37. doi: 10.1002/hbm.20598. PubMed PMID:18537113 PubMed Central PMC6871248.


  1. Nicolakakis, N, Aboulkassim, T, Ongali, B, Lecrux, C, Fernandes, P, Rosa-Neto, P et al.. Complete rescue of cerebrovascular function in aged Alzheimer’s disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. J Neurosci. 2008;28 (37):9287-96. doi: 10.1523/JNEUROSCI.3348-08.2008. PubMed PMID:18784309 PubMed Central PMC6670922.
  2. Oishi, K, Zilles, K, Amunts, K, Faria, A, Jiang, H, Li, X et al.. Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matter. Neuroimage. 2008;43 (3):447-57. doi: 10.1016/j.neuroimage.2008.07.009. PubMed PMID:18692144 PubMed Central PMC2586008.
  3. Frey, BN, Rosa-Neto, P, Lubarsky, S, Diksic, M. Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: a combined alpha-[11C]MT and [18F]MPPF positron emission tomography study. Neuroimage. 2008;42 (2):850-7. doi: 10.1016/j.neuroimage.2008.05.009. PubMed PMID:18583156 .
  4. Chen, ZJ, He, Y, Rosa-Neto, P, Germann, J, Evans, AC. Revealing modular architecture of human brain structural networks by using cortical thickness from MRI. Cereb Cortex. 2008;18 (10):2374-81. doi: 10.1093/cercor/bhn003. PubMed PMID:18267952 PubMed Central PMC2733312.


  1. Rosa-Neto, P, Benkelfat, C, Sakai, Y, Leyton, M, Morais, JA, Diksic, M et al.. Brain regional alpha-[11C]methyl-L-tryptophan trapping, used as an index of 5-HT synthesis, in healthy adults: absence of an age effect. Eur J Nucl Med Mol Imaging. 2007;34 (8):1254-64. doi: 10.1007/s00259-007-0365-x. PubMed PMID:17318550 .
  2. Pedersen, K, Simonsen, M, Østergaard, SD, Munk, OL, Rosa-Neto, P, Olsen, AK et al.. Mapping the amphetamine-evoked changes in [11C]raclopride binding in living rat using small animal PET: modulation by MAO-inhibition. Neuroimage. 2007;35 (1):38-46. doi: 10.1016/j.neuroimage.2006.11.038. PubMed PMID:17223363 .


  1. Doudet, DJ, Rosa-Neto, P, Munk, OL, Ruth, TJ, Jivan, S, Cumming, P et al.. Effect of age on markers for monoaminergic neurons of normal and MPTP-lesioned rhesus monkeys: a multi-tracer PET study. Neuroimage. 2006;30 (1):26-35. doi: 10.1016/j.neuroimage.2005.09.044. PubMed PMID:16378735 .
  2. Leyton, M, Paquette, V, Gravel, P, Rosa-Neto, P, Weston, F, Diksic, M et al.. alpha-[11C]Methyl-L-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. Eur Neuropsychopharmacol. 2006;16 (3):220-3. doi: 10.1016/j.euroneuro.2005.09.006. PubMed PMID:16269239 .


  1. Rosa-Neto, P, Diksic, M, Leyton, M, Mzengeza, S, Benkelfat, C. Stability of alpha-[11C]methyl-L-tryptophan brain trapping in healthy male volunteers. Eur J Nucl Med Mol Imaging. 2005;32 (10):1199-204. doi: 10.1007/s00259-005-1829-5. PubMed PMID:15948006 .
  2. Rosa-Neto, P, Lou, HC, Cumming, P, Pryds, O, Karrebaek, H, Lunding, J et al.. Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder. Neuroimage. 2005;25 (3):868-76. doi: 10.1016/j.neuroimage.2004.11.031. PubMed PMID:15808987 .
  3. Gjedde, A, Wong, DF, Rosa-Neto, P, Cumming, P. Mapping neuroreceptors at work: on the definition and interpretation of binding potentials after 20 years of progress. Int Rev Neurobiol. 2005;63 :1-20. doi: 10.1016/S0074-7742(05)63001-2. PubMed PMID:15797463 .


  1. Rosa-Neto, P, Gjedde, A, Olsen, AK, Jensen, SB, Munk, OL, Watanabe, H et al.. MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain. Synapse. 2004;53 (4):222-33. doi: 10.1002/syn.20053. PubMed PMID:15266554 .
  2. Rosa-Neto, P, Olsen, AK, Gjedde, A, Watanabe, H, Cumming, P. MDMA-evoked changes in cerebral blood flow in living porcine brain: correlation with hyperthermia. Synapse. 2004;53 (4):214-21. doi: 10.1002/syn.20052. PubMed PMID:15266553 .
  3. Rosa-Neto, P, Doudet, DJ, Cumming, P. Gradients of dopamine D1- and D2/3-binding sites in the basal ganglia of pig and monkey measured by PET. Neuroimage. 2004;22 (3):1076-83. doi: 10.1016/j.neuroimage.2004.03.004. PubMed PMID:15219579 .
  4. Rosa-Neto, P, Diksic, M, Okazawa, H, Leyton, M, Ghadirian, N, Mzengeza, S et al.. Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Arch Gen Psychiatry. 2004;61 (6):556-63. doi: 10.1001/archpsyc.61.6.556. PubMed PMID:15184235 .


  1. Cumming, P, Rosa-Neto, P, Watanabe, H, Smith, D, Bender, D, Clarke, PB et al.. Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain. Neuroimage. 2003;19 (3):1127-36. doi: 10.1016/s1053-8119(03)00079-x. PubMed PMID:12880838 .


  1. Rosa Neto, P, Lou, H, Cumming, P, Pryds, O, Gjedde, A. Methylphenidate-evoked potentiation of extracellular dopamine in the brain of adolescents with premature birth: correlation with attentional deficit. Ann N Y Acad Sci. 2002;965 :434-9. doi: 10.1111/j.1749-6632.2002.tb04184.x. PubMed PMID:12105118 .


  1. Bernasconi, A, Martinez, V, Rosa-Neto, P, D’Agostino, D, Bernasconi, N, Berkovic, S et al.. Surgical resection for intractable epilepsy in “double cortex” syndrome yields inadequate results. Epilepsia. 2001;42 (9):1124-9. doi: 10.1046/j.1528-1157.2001.39900.x. PubMed PMID:11580758 .


  1. Lopes-Cendes, I, Teive, HG, Calcagnotto, ME, Da Costa, JC, Cardoso, F, Viana, E et al.. Frequency of the different mutations causing spinocerebellar ataxia (SCA1, SCA2, MJD/SCA3 and DRPLA) in a large group of Brazilian patients. Arq Neuropsiquiatr. 1997;55 (3B):519-29. doi: 10.1590/s0004-282×1997000400001. PubMed PMID:9629399 .